Loss of our natural appetite usually means there is something wrong. Spiritually, it can mean the same. God made us to hunger for His presence. Even good things can take away our hunger for God – even things like our busyness in our work for Him. There is always the temptation to fill our time with good things, and miss the best that God has for us. God wants us to feast on Him, to spend time in His presence, and for His presence to be the pinnacle of our lives. We should desire God above all else (John 7:37-38).